USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

USC-OGP 2-DE database  Search by                Maps             Select Remote Interfaces [All Interfaces] SWISS-2DPAGE World-2DPAGE Portal World-2DPAGE Repository Exclude local DBs has only effect if a remote interface is selected

Searching in 'USC-OGP 2-DE database' for entry matching: P07996 USC-OGP 2-DE database:  P07996 P07996 General information about the entry View entry in simple text format Entry name TSP1_HUMAN Primary accession number P07996 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Thrombospondin-1; Flags: Precursor;. Gene name Name=THBS1 Synonyms=TSP, TSP1 Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein PLATELET_4-7 {PLATELET 4-7} Homo sapiens (Human)   map experimental info   PLATELET_4-7 MAP LOCATIONS: SPOT OGP-0463: pI=5.37; Mw=33896 SPOT OGP-0474: pI=5.67; Mw=31502 SPOT OGP-0476: pI=5.21; Mw=31348 SPOT OGP-0518: pI=6.67; Mw=26242 SPOT OGP-0525: pI=6.67; Mw=25695 PLATELET_5-6 {PLATELET 5-6} Homo sapiens (Human)   map experimental info   PLATELET_5-6 MAP LOCATIONS: SPOT OGP-0763: pI=5.67; Mw=32155 PLATELET_6-11 {PLATELET 6-11} Homo sapiens (Human)   map experimental info   PLATELET_6-11 MAP LOCATIONS: SPOT OGP-1011: pI=6.60; Mw=26072 SPOT OGP-1014: pI=6.60; Mw=25471 Cross-references UniProtKB/Swiss-Prot P07996; TSP1_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name TSP1_HUMAN Primary accession number P07996 Secondary accession number(s) A8K6H4 B4E3J7 B9EGH6 Q15667 Q59E99 Sequence was last modified on  October 31, 2006 (version 2) Annotations were last modified on  February 15, 2017 (version 212) Name and origin of the protein Description RecName: Full=Thrombospondin-1; Flags: Precursor; Gene name Name=THBS1 Synonyms=TSP, TSP1 Encoded on Name=THBS1; Synonyms=TSP, TSP1 Keywords 3D-structure; Alternative splicing; Calcium; Cell adhesion; Complete proteome; Disulfide bond; EGF-like domain; Endoplasmic reticulum; Glycoprotein; Heparin-binding; Polymorphism; Reference proteome; Repeat; Sarcoplasmic reticulum; Signal; Unfolded protein response. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL X04665; CAA28370.1; -; mRNA EMBL X14787; CAA32889.1; -; mRNA EMBL AK291639; BAF84328.1; -; mRNA EMBL AK304754; BAG65509.1; -; mRNA EMBL AB209912; BAD93149.1; ALT_INIT; mRNA EMBL AC037198; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL BC136469; AAI36470.1; -; mRNA EMBL BC136470; AAI36471.1; -; mRNA EMBL M25631; AAA36741.1; -; mRNA EMBL M14326; AAA61237.1; ALT_SEQ; mRNA EMBL J04835; AAA61178.1; -; Genomic_DNA EMBL M99425; AAB59366.1; -; mRNA CCDS CCDS32194.1; -. [P07996-1]; . PIR A26155; TSHUP1; . RefSeq NP_003237.2; NM_003246.3. [P07996-1]; . UniGene Hs.164226; -; . UniGene Hs.732539; -; . PDB 1LSL; X-ray; 1.90 A; A=434-546 PDB 1UX6; X-ray; 1.90 A; A=834-1170 PDB 1Z78; X-ray; 1.80 A; A=19-233 PDB 1ZA4; X-ray; 1.90 A; A=19-233 PDB 2ERF; X-ray; 1.45 A; A=25-233 PDB 2ES3; X-ray; 1.85 A; A/B=25-233 PDB 2OUH; X-ray; 2.40 A; A/B=19-257 PDB 2OUJ; X-ray; 1.90 A; A=19-257 PDB 3R6B; X-ray; 2.40 A; A=434-547 PDB 5FOE; X-ray; 1.98 A; A/B=378-429 PDBsum 1LSL; -; . PDBsum 1UX6; -; . PDBsum 1Z78; -; . PDBsum 1ZA4; -; . PDBsum 2ERF; -; . PDBsum 2ES3; -; . PDBsum 2OUH; -; . PDBsum 2OUJ; -; . PDBsum 3R6B; -; . PDBsum 5FOE; -; . ProteinModelPortal P07996; -; . SMR P07996; -; . BioGrid 112915; 33; . DIP DIP-1037N; -; . IntAct P07996; 14; . MINT MINT-6630675; -; . STRING 9606.ENSP00000260356; -; . iPTMnet P07996; -; . PhosphoSitePlus P07996; -; . UniCarbKB P07996; -; . BioMuta THBS1; -; . DMDM 117949802; -; . OGP P07996; -; . EPD P07996; -; . MaxQB P07996; -; . PaxDb P07996; -; . PeptideAtlas P07996; -; . PRIDE P07996; -; . Ensembl ENST00000260356; ENSP00000260356; ENSG00000137801. [P07996-1]; . GeneID 7057; -; . KEGG hsa:7057; -; . UCSC uc001zkh.4; human. [P07996-1]; . CTD 7057; -; . DisGeNET 7057; -; . GeneCards THBS1; -; . H-InvDB HIX0038125; -; . HGNC HGNC:11785; THBS1; . HPA CAB033678; -; . HPA HPA059756; -; . MIM 188060; gene; . neXtProt NX_P07996; -; . OpenTargets ENSG00000137801; -; . PharmGKB PA36497; -; . eggNOG ENOG410IFQQ; Eukaryota; . eggNOG ENOG410XQKE; LUCA; . GeneTree ENSGT00850000132273; -; . HOGENOM HOG000007542; -; . HOVERGEN HBG018006; -; . InParanoid P07996; -; . KO K16857; -; . OMA TPQFGGK; -; . OrthoDB EOG091G00TV; -; . PhylomeDB P07996; -; . TreeFam TF324917; -; . Reactome R-HSA-114608; Platelet degranulation; . Reactome R-HSA-186797; Signaling by PDGF; . Reactome R-HSA-216083; Integrin cell surface interactions; . Reactome R-HSA-3000170; Syndecan interactions; . Reactome R-HSA-5083635; Defective B3GALTL causes Peters-plus syndrome (PpS); . Reactome R-HSA-5173214; O-glycosylation of TSR domain-containing proteins; . SIGNOR P07996; -; . ChiTaRS THBS1; human; . EvolutionaryTrace P07996; -; . GeneWiki Thrombospondin_1; -; . GenomeRNAi 7057; -; . PMAP-CutDB P07996; -; . PRO PR:P07996; -; . Proteomes UP000005640; Chromosome 15; . Bgee ENSG00000137801; -; . CleanEx HS_THBS1; -; . ExpressionAtlas P07996; baseline and differential; . Genevisible P07996; HS; . GO GO:0009986; C:cell surface; IDA:BHF-UCL; . GO GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB; . GO GO:0005788; C:endoplasmic reticulum lumen; TAS:Reactome; . GO GO:0009897; C:external side of plasma membrane; IDA:BHF-UCL; . GO GO:0070062; C:extracellular exosome; IDA:UniProtKB; . GO GO:0031012; C:extracellular matrix; IDA:UniProtKB; . GO GO:0005576; C:extracellular region; TAS:Reactome; . GO GO:0005615; C:extracellular space; IDA:UniProtKB; . GO GO:0005577; C:fibrinogen complex; IDA:BHF-UCL; . GO GO:0031091; C:platelet alpha granule; IDA:BHF-UCL; . GO GO:0031093; C:platelet alpha granule lumen; TAS:Reactome; . GO GO:0016529; C:sarcoplasmic reticulum; ISS:UniProtKB; . GO GO:0030141; C:secretory granule; IDA:BHF-UCL; . GO GO:0005509; F:calcium ion binding; NAS:BHF-UCL; . GO GO:0070052; F:collagen V binding; IDA:BHF-UCL; . GO GO:0070051; F:fibrinogen binding; IDA:BHF-UCL; . GO GO:0017134; F:fibroblast growth factor binding; IDA:BHF-UCL; . GO GO:0001968; F:fibronectin binding; IDA:BHF-UCL; . GO GO:0001948; F:glycoprotein binding; NAS:BHF-UCL; . GO GO:0008201; F:heparin binding; IDA:BHF-UCL; . GO GO:0042802; F:identical protein binding; NAS:BHF-UCL; . GO GO:0005178; F:integrin binding; IMP:BHF-UCL; . GO GO:0043236; F:laminin binding; IDA:BHF-UCL; . GO GO:0030169; F:low-density lipoprotein particle binding; IDA:BHF-UCL; . GO GO:0001786; F:phosphatidylserine binding; IDA:UniProtKB; . GO GO:0043394; F:proteoglycan binding; TAS:BHF-UCL; . GO GO:0050431; F:transforming growth factor beta binding; ISS:BHF-UCL; . GO GO:0000187; P:activation of MAPK activity; IMP:BHF-UCL; . GO GO:0048266; P:behavioral response to pain; ISS:UniProtKB; . GO GO:0007155; P:cell adhesion; NAS:BHF-UCL; . GO GO:0007050; P:cell cycle arrest; IDA:BHF-UCL; . GO GO:0016477; P:cell migration; IDA:BHF-UCL; . GO GO:0071363; P:cellular response to growth factor stimulus; IEA:Ensembl; . GO GO:0034605; P:cellular response to heat; NAS:BHF-UCL; . GO GO:0071356; P:cellular response to tumor necrosis factor; IEA:Ensembl; . GO GO:0002544; P:chronic inflammatory response; IEP:BHF-UCL; . GO GO:0043652; P:engulfment of apoptotic cell; IDA:BHF-UCL; . GO GO:0030198; P:extracellular matrix organization; TAS:Reactome; . GO GO:0006955; P:immune response; IEP:BHF-UCL; . GO GO:0006954; P:inflammatory response; IDA:CACAO; . GO GO:0016525; P:negative regulation of angiogenesis; IDA:UniProtKB; . GO GO:0002581; P:negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II; IDA:BHF-UCL; . GO GO:0043066; P:negative regulation of apoptotic process; IDA:UniProtKB; . GO GO:0043537; P:negative regulation of blood vessel endothelial cell migration; IDA:BHF-UCL; . GO GO:0001953; P:negative regulation of cell-matrix adhesion; IDA:BHF-UCL; . GO GO:0010754; P:negative regulation of cGMP-mediated signaling; IDA:BHF-UCL; . GO GO:0043154; P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; IDA:UniProtKB; . GO GO:0002605; P:negative regulation of dendritic cell antigen processing and presentation; IDA:BHF-UCL; . GO GO:2001027; P:negative regulation of endothelial cell chemotaxis; IDA:MGI; . GO GO:0010596; P:negative regulation of endothelial cell migration; IDA:BHF-UCL; . GO GO:0001937; P:negative regulation of endothelial cell proliferation; IDA:BHF-UCL; . GO GO:2001237; P:negative regulation of extrinsic apoptotic signaling pathway; TAS:BHF-UCL; . GO GO:0051918; P:negative regulation of fibrinolysis; IDA:BHF-UCL; . GO GO:0040037; P:negative regulation of fibroblast growth factor receptor signaling pathway; IDA:BHF-UCL; . GO GO:0051895; P:negative regulation of focal adhesion assembly; TAS:BHF-UCL; . GO GO:0032695; P:negative regulation of interleukin-12 production; IDA:BHF-UCL; . GO GO:0010751; P:negative regulation of nitric oxide mediated signal transduction; IDA:BHF-UCL; . GO GO:0010748; P:negative regulation of plasma membrane long-chain fatty acid transport; IDA:BHF-UCL; . GO GO:0010757; P:negative regulation of plasminogen activation; IDA:BHF-UCL; . GO GO:0018149; P:peptide cross-linking; IDA:BHF-UCL; . GO GO:0002576; P:platelet degranulation; TAS:Reactome; . GO GO:0045766; P:positive regulation of angiogenesis; IMP:BHF-UCL; . GO GO:0030194; P:positive regulation of blood coagulation; IDA:BHF-UCL; . GO GO:0043536; P:positive regulation of blood vessel endothelial cell migration; IDA:BHF-UCL; . GO GO:0030335; P:positive regulation of cell migration; IDA:BHF-UCL; . GO GO:0008284; P:positive regulation of cell proliferation; IDA:BHF-UCL; . GO GO:0050921; P:positive regulation of chemotaxis; IDA:BHF-UCL; . GO GO:2000353; P:positive regulation of endothelial cell apoptotic process; IDA:UniProtKB; . GO GO:0010595; P:positive regulation of endothelial cell migration; IDA:BHF-UCL; . GO GO:1902043; P:positive regulation of extrinsic apoptotic signaling pathway via death domain receptors; IDA:BHF-UCL; . GO GO:0010763; P:positive regulation of fibroblast migration; IDA:BHF-UCL; . GO GO:0043032; P:positive regulation of macrophage activation; IDA:BHF-UCL; . GO GO:0010759; P:positive regulation of macrophage chemotaxis; ISS:BHF-UCL; . GO GO:0042327; P:positive regulation of phosphorylation; IMP:BHF-UCL; . GO GO:0051897; P:positive regulation of protein kinase B signaling; IDA:UniProtKB; . GO GO:2000379; P:positive regulation of reactive oxygen species metabolic process; IDA:BHF-UCL; . GO GO:0048661; P:positive regulation of smooth muscle cell proliferation; IDA:BHF-UCL; . GO GO:0030511; P:positive regulation of transforming growth factor beta receptor signaling pathway; IDA:BHF-UCL; . GO GO:0032914; P:positive regulation of transforming growth factor beta1 production; ISS:BHF-UCL; . GO GO:0045727; P:positive regulation of translation; IDA:BHF-UCL; . GO GO:0042535; P:positive regulation of tumor necrosis factor biosynthetic process; IDA:UniProtKB; . GO GO:0036066; P:protein O-linked fucosylation; TAS:Reactome; . GO GO:0030823; P:regulation of cGMP metabolic process; IDA:MGI; . GO GO:0051592; P:response to calcium ion; IDA:BHF-UCL; . GO GO:0042493; P:response to drug; IEP:UniProtKB; . GO GO:0034976; P:response to endoplasmic reticulum stress; ISS:UniProtKB; . GO GO:0009749; P:response to glucose; IDA:BHF-UCL; . GO GO:0001666; P:response to hypoxia; NAS:BHF-UCL; . GO GO:0032026; P:response to magnesium ion; IDA:BHF-UCL; . GO GO:0009612; P:response to mechanical stimulus; IEA:Ensembl; . GO GO:0032570; P:response to progesterone; TAS:BHF-UCL; . GO GO:0033574; P:response to testosterone; IEA:Ensembl; . GO GO:0006986; P:response to unfolded protein; IEA:UniProtKB-KW; . GO GO:0002040; P:sprouting angiogenesis; IMP:BHF-UCL; . Gene3D 2.60.120.200; -; 3; . Gene3D 4.10.1080.10; -; 2; . InterPro IPR013320; ConA-like_dom; . InterPro IPR001881; EGF-like_Ca-bd_dom; . InterPro IPR013032; EGF-like_CS; . InterPro IPR000742; EGF-like_dom; . InterPro IPR001791; Laminin_G; . InterPro IPR028499; Thrombospondin-1; . InterPro IPR003367; Thrombospondin_3-like_rpt; . InterPro IPR017897; Thrombospondin_3_rpt; . InterPro IPR008859; Thrombospondin_C; . InterPro IPR000884; TSP1_rpt; . InterPro IPR028974; TSP_type-3_rpt; . InterPro IPR001007; VWF_dom; . PANTHER PTHR10199:SF101; PTHR10199:SF101; 1; . Pfam PF00090; TSP_1; 3; . Pfam PF02412; TSP_3; 7; . Pfam PF05735; TSP_C; 1; . Pfam PF00093; VWC; 1; . SMART SM00181; EGF; 3; . SMART SM00179; EGF_CA; 2; . SMART SM00209; TSP1; 3; . SMART SM00210; TSPN; 1; . SMART SM00214; VWC; 1; . SUPFAM SSF103647; SSF103647; 3; . SUPFAM SSF49899; SSF49899; 2; . SUPFAM SSF82895; SSF82895; 3; . PROSITE PS01186; EGF_2; 1; . PROSITE PS50026; EGF_3; 2; . PROSITE PS50092; TSP1; 3; . PROSITE PS51234; TSP3; 8; . PROSITE PS51236; TSP_CTER; 1; . PROSITE PS01208; VWFC_1; 1; . PROSITE PS50184; VWFC_2; 1; .

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